Reprogramming mouse embryonic fibroblasts using different reprogramming factors
نویسندگان
چکیده
منابع مشابه
Reprogramming fibroblasts into cardiomyocytes.
A deficiency of cardiomyocytes underlies most cases of heart failure, and scientists have long sought to repopulate the heart with new cardiomyocytes. Most attempts at remuscularization have been based on the transplantation of stem cells or their derivatives, and success has been modest to date. A recent study by Ieda and colleagues1 points to a new therapeutic strategy: reprogramming fibrobla...
متن کاملReprogramming of HumanHuntington Fibroblasts Using mRNA
1 Fraunhofer Institute for Cell Therapy and Immunology, Perlickstraβe 1, 04103 Leipzig, Germany 2 Institute of Virology, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany 3 Interdisciplinary Centre for Bioinformatics, University of Leipzig, Härtelstraβe 16-18, 04107 Leipzig, Germany 4Department Stereotactic and Functional Neurosurgery, University Hospital of Freiburg, Breisacher S...
متن کاملPluripotent State Induction in Mouse Embryonic Fibroblast Using mRNAs of Reprogramming Factors
Reprogramming of somatic cells has great potential to provide therapeutic treatments for a number of diseases as well as provide insight into mechanisms underlying early embryonic development. Improvement of induced Pluripotent Stem Cells (iPSCs) generation through mRNA-based methods is currently an area of intense research. This approach provides a number of advantages over previously used met...
متن کاملMicroRNAs Are Indispensable for Reprogramming Mouse Embryonic Fibroblasts into Induced Stem Cell-Like Cells
MicroRNAs play a pivotal role in cellular maintenance, proliferation, and differentiation. They have also been implicated to play a key role in disease pathogenesis, and more recently, cellular reprogramming. Certain microRNA clusters can enhance or even directly induce reprogramming, while repressing key proteins involved in microRNA processing decreases reprogramming efficiency. Although micr...
متن کاملDirect reprogramming of fibroblasts into embryonic Sertoli-like cells by defined factors.
Sertoli cells are considered the "supporting cells" of the testis that play an essential role in sex determination during embryogenesis and in spermatogenesis during adulthood. Their essential roles in male fertility along with their immunosuppressive and neurotrophic properties make them an attractive cell type for therapeutic applications. Here we demonstrate the generation of induced embryon...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Protocol Exchange
سال: 2015
ISSN: 2043-0116
DOI: 10.1038/protex.2015.063